4-氟-1H-异吲哚-1,3(2H)-二酮合成路线 （共 5 条）
反应条件
1: methanol With iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid T=0°C; 0.166667 h; Inert atmosphere; 2: 3-fluorophthalimide With 1,8-diazabicyclo[5.4.0]undec-7-ene T=0 - 20°C; Hofmann-type rearrangement; 4 h; Inert atmosphere; regioselective reaction;
参考文献
Moriyama, Katsuhiko; Ishida, Kazuma; Togo, Hideo
Organic Letters, 2012 , vol. 14, # 3 p. 946 - 949
反应条件
1: With borane-THF 18 h; Heating / reflux; 2: With hydrogenchloride in methanol; water T=63°C; 1 h; Heating / reflux;
参考文献
INTERMUNE, INC.; ARRAY BIOPHARMA INC.
Patent: WO2005/37214 A2, 2005 ;
Location in patent: Page/Page column 179 ;
反应条件
formamide
T=130°C; 1 h; Inert atmosphere;
参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
Location in patent: Page/Page column 114 ;
反应条件
thionyl chloride; potassium fluoride; urea in sulfolane; water; acetone
参考文献
BASF Aktiengesellschaft
Patent: US4680412 A1, 1987 ;
反应条件
1: ethanol; sodium tetrahydroborate / 0 - 20 °C
2: trifluoroacetic acid; triethylsilane / dichloromethane / 20 °C
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参考文献
BAYER SCHERING PHARMA AKTIEGESELLSCHAFT
Patent: US2011/34450 A1, 2011 ;
