1: 2-methoxy-6-bromo-naphthalene With magnesium; ethylene dibromide in diethyl ether
Inert atmosphereReflux;
2: 2,2,2-trifluoro-N-methoxy-N-methylacetamide in diethyl ether
T=0 - 20°C;
3: With hydrogenchloride in diethyl ether; water
1: trimethylsilylacetylene With ethylmagnesium bromide in tetrahydrofuran
Heating;
2: 2-methoxy-6-bromo-naphthalene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; benzene
Heating;
参考文献
Carpita, Adriano; Ribecai, Arianna; Rossi, Renzo; Stabile, Paolo
Tetrahedron, 2002 , vol. 58, # 19 p. 3673 - 3680
1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide
T=20°C; Heck reaction; 0.25 h;
2: 2-methoxy-6-bromo-naphthalene With Kaiser oxime-derived complex on resin base in N,N-dimethyl acetamide
T=120°C; Heck reaction; 14 h; Further stages. Title compound not separated from byproducts.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
1: 3-hydroxy-1-butene With α-cyclohexylcyclohexanemethanamine; tetrabutylammomium bromide in N,N-dimethyl acetamide
T=20°C; Heck reaction; 0.25 h;
2: 2-methoxy-6-bromo-naphthalene With Kaiser oxime-derived complex on resin base in N,N-dimethyl acetamide
T=120°C; Heck reaction; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2572 - 2584
