1.1: POCl3 / 0.5 h / 0 °C
1.2: 73 percent / 4 h / 80 °C
2.1: 53 percent / NaOEt / diethyl ether; ethanol / 3 h / -10 - 20 °C
3.1: 52 percent / toluene / 6 h / Heating
View Scheme
参考文献
Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896
