3-甲基-1,2-苯异噁唑-4-醇合成路线 （共 5 条）
反应条件
pyridine
2 h; Reflux;
参考文献
AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles
Patent: WO2012/76877 A1, 2012 ;
Location in patent: Page/Page column 64-65 ;
WO 2012/076877 A1
反应条件
potassium hydroxide in methanol
24 h; Heating;
参考文献
Crabbe,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2220 - 2222
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 2.5 h / Reflux; Inert atmosphere
2: 0.25 h / 20 °C
3: pyridine / 2 h / Reflux
View Scheme
参考文献
AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles
Patent: WO2012/76877 A1, 2012 ;
WO 2012/076877 A1
反应条件
1: 73 percent / K2CO3 / acetone / 11 h / Heating
2: 57 percent / ethanol / 2 h / Heating
View Scheme
参考文献
Franke; Frickel; Gries; Lehmann; Lenke; Ohnsorge
Arzneimittel-Forschung, 1980 , vol. 30, # 11 p. 1831 - 1838
反应条件
potassium carbonate in acetone
11 h; Heating;
参考文献
Franke; Frickel; Gries; Lehmann; Lenke; Ohnsorge
Arzneimittel-Forschung, 1980 , vol. 30, # 11 p. 1831 - 1838
