2-亚甲基-4-戊烯酸甲酯合成路线 （共 11 条）
反应条件
2,6-dichloro-benzonitrile in benzene
Heating;
参考文献
Yu, Lin-Chen; Helquist, Paul
Synthetic Communications, 1981 , vol. 11, # 7 p. 591 - 598
反应条件
sodium hydroxide in diethyl ether
Ambient temperature;
参考文献
Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Moroder, Fabio; Pollini, Gian Piero; et al.
Journal of the Chemical Society, Chemical Communications, 1982 , # 21 p. 1265 - 1266
反应条件
DBN in benzene
3 h; Ambient temperature;
参考文献
Seebach, Dieter; Henning, Rainer; Mukhopadhyay, Triptikumar
Chemische Berichte, 1982 , vol. 115, # 5 p. 1705 - 1720
反应条件
1: 100 percent / methanol / 25 °C
2: 87 percent / DBN / benzene / Heating
View Scheme
参考文献
Yu, Lin-Chen; Helquist, Paul
Synthetic Communications, 1981 , vol. 11, # 7 p. 591 - 598
反应条件
in diphenylether
T=179 - 190°C;
参考文献
Kimura,R. et al.
Synthesis, 1979 , p. 516 - 518
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisobutylaluminium hydride
1.) THF, hexane, 0 deg C, 1 h, 2.) THF, hexane, RT, 15 h; Yield given. Multistep reaction;
参考文献
Tsuda, Tetsuo; Yoshida, Tsutomu; Kawamoto, Tadashi; Saegusa, Takeo
Journal of Organic Chemistry, 1987 , vol. 52, # 8 p. 1624 - 1627
反应条件
in N,N-dimethyl-formamide
参考文献
Miller,R.B.; Smith,B.F.
Synthetic Communications, 1973 , vol. 3, p. 359 - 363
反应条件
1: (i) Me2NH*HCl, aq. dioxane, (ii) NaOH, (iii) /BRN= 969135/
2: dimethylformamide
View Scheme
参考文献
Miller,R.B.; Smith,B.F.
Synthetic Communications, 1973 , vol. 3, p. 359 - 363
参考文献
Yu,L.-C.; Helquist,P.
Tetrahedron Letters, 1978 , p. 3423 - 3426
反应条件
1: 65 percent / KOH / methanol; H2O / 20 °C
2: 100 percent / KI, I2, NaHCO3 / H2O / 20 °C
3: 26 percent / DBU / benzene / 60 °C
View Scheme
参考文献
Yu, Lin-Chen; Helquist, Paul
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4536 - 4541
