2-苯并噻唑丙胺(9ci)合成路线 （共 5 条）
反应条件
polyphosphoric acid
T=220°C; 4 h;
参考文献
Keri, Rangappa S.; Quintanova, Catarina; Marques, Sergio M.; Esteves, A. Raquel; Cardoso, Sandra M.; Santos, M. Amelia
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4559 - 4569
反应条件
hydrazine in chloroform
20 h;
参考文献
Atwal, Karnail S.; O'Reilly, Brian C.; Ruby, Eric P.; Turk, Chester F.; Aberg, Gunnar; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 627 - 635
反应条件
1: 76.7 percent / dimethylsulfoxide / 3 h / 80 °C
2: hydrazine / CHCl3 / 20 h
View Scheme
参考文献
Atwal, Karnail S.; O'Reilly, Brian C.; Ruby, Eric P.; Turk, Chester F.; Aberg, Gunnar; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 627 - 635
反应条件
1: 63.5 percent / diisopropylethylamine / tetrahydrofuran / a) RT, 2 h, b) 80 deg C, 14 h
2: 76.7 percent / dimethylsulfoxide / 3 h / 80 °C
3: hydrazine / CHCl3 / 20 h
View Scheme
参考文献
Atwal, Karnail S.; O'Reilly, Brian C.; Ruby, Eric P.; Turk, Chester F.; Aberg, Gunnar; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 627 - 635
反应条件
toluene-4-sulfonic acid
参考文献
Botta,A.
Justus Liebigs Annalen der Chemie, 1976 , p. 336 - 347
