(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
hydrogen; diacetato[(R)-(+)-2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl]ruthenium(II) in methanol P=76000 Torr; 8 h; Ambient temperature;
参考文献
Uemura, Toshitsugi; Zhang, Xiaoyoung; Matsumura, Kazuhiko; Sayo, Noboru; Kumobayashi, Hidenori; Ohta, Tetsuo; Nozaki, Kyoko; Takaya, Hidemasa
Journal of Organic Chemistry, 1996 , vol. 61, # 16 p. 5510 - 5516
反应条件
Birman's catalyst; 4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Shiina, Isamu; Nakata, Kenya
Patent: US2010/234610 A1, 2010 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1: With dimethyl sulfoxide; Candida rugosa lipase T=40°C; pH=9.8; 144 h; aq. buffer; 2: With hydrogenchloride in water pH=5; optical yield given as percent eeenantioselective reaction;
参考文献
Chavez-Flores, David; Salvador, James M.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 237 - 239
反应条件
hydrogen; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; triethylamine; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in methanol; toluene T=20°C; Catalytic hydrogenation; P=60800 Torr; 24 h; Product distribution; Further Variations:Reagents;
参考文献
Fan, Qing-Hua; Wang, Rui; Chan, Albert S.C
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 14 p. 1867 - 1871
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 6 h; Resolution of racemate;
参考文献
Shiina, Isamu; Nakata, Kenya
Patent: US2010/234610 A1, 2010 ;
Location in patent: Page/Page column 11-12 ;
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in water; acetonitrile T=35°C; 4 h; aq. phosphate buffer;
参考文献
Galletti, Paola; Pori, Matteo; Giacomini, Daria
Synlett, 2010 , # 17 p. 2644 - 2648
反应条件
hydrogenchloride in n-heptane; water
参考文献
The Boots Company PLC
Patent: US5696165 A1, 1997 ;
反应条件
4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 12 h; Resolution of racemate;
参考文献
Nakata, Kenya; Onda, Yu-Suke; Ono, Keisuke; Shiina, Isamu
Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5666 - 5669
反应条件
1: With Rh(ethylene)2(hydrotris(pyrazolyl)borate); dibenzylideneacetone; lithium bromide in diethyl ether T=0°C; 2: With ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C;
参考文献
Evans, P. Andrew; Uraguchi, Daisuke
Journal of the American Chemical Society, 2003 , vol. 125, # 24 p. 7158 - 7159
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 6 h; Resolution of racemate;
参考文献
Shiina, Isamu; Nakata, Kenya
Patent: US2010/234610 A1, 2010 ;
Location in patent: Page/Page column 11-12 ;
