(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
1: pig pancreatic lipase; phosphate buffer / acetone / pH 8.0 2: pyridinium dichromate / dimethylformamide / 72 h View Scheme
参考文献
Basak, Amit; Nag, Ahindra; Bhattacharya, Gautam; Mandal, Subrata; Nag, Sikha
Tetrahedron Asymmetry, 2000 , vol. 11, # 11 p. 2403 - 2407
反应条件
1: 79 percent / Me3Al / CH2Cl2 / Heating 2: n-BuLi, N,N-dimethylpropyleneurea / -60 °C 3: 89 percent / LiOH, H2O2 / tetrahydrofuran; H2O View Scheme
参考文献
Oppolzer, Wolfgang; Rosset, Stephane; De Brabander, Jef
Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1539 - 1540
反应条件
1: 97 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 2: 54 percent / CrO3, H2SO4 / acetone / 0.5 h / 0 °C View Scheme
参考文献
Bando, Toshikazu; Namba, Yukiko; Shishido, Kozo
Tetrahedron Asymmetry, 1997 , vol. 8, # 13 p. 2159 - 2165
反应条件
1: n-BuLi, N,N-dimethylpropyleneurea / -60 °C 2: 89 percent / LiOH, H2O2 / tetrahydrofuran; H2O View Scheme
参考文献
Oppolzer, Wolfgang; Rosset, Stephane; De Brabander, Jef
Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1539 - 1540
反应条件
hydrogenchloride in water; acetone 3 h; Heating;
参考文献
Svoboda, Jiri; Capek, Karel; Palecek, Jaroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 3 p. 766 - 774
反应条件
1: methanol / Heating 2: Acid hydrolysis View Scheme
参考文献
Sarakinos, Georgios; Corey
Organic Letters, 1999 , vol. 1, # 11 p. 1741 - 1744
反应条件
1: triethylamine / dichloromethane / 20 °C 2: hydrogenchloride / aq. buffer / 37 °C / pH 7.4 / |Sealed tube View Scheme
参考文献
Chandiran, Senthil; Vyas, Sandeep; Sharma, Neetika; Sharma, Manu
Medicinal Chemistry, 2013 , vol. 9, # 7 p. 1006 - 1016
反应条件
sodium hydroxide in water 11 h; Ambient temperaturehorse liver esterase, pH 7.2; Yield given. Yields of byproduct given;
参考文献
Ahmar, M.; Girard, C.; Bloch, R.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7053 - 7056
反应条件
Candida rugosa lipase MY; sodium lauryl sulfate in water 18 h;
参考文献
Mori, Shuichi; Yumoto, Hiromi; Matsumi, Rina; Nishigaki, Tomohiro; Ebara, Yasuhito; Ueji, Shin-Ichi
Tetrahedron Asymmetry, 2005 , vol. 16, # 22 p. 3698 - 3702
反应条件
1.1: Cu(CF3SO3)2(NCH(C6H5)CH2OC)2C(CH3)2 / dichloromethane / 6 h / 20 °C / Inert atmosphere 2.1: dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 0 °C / Inert atmosphere 2.2: 0 °C / pH 1 / Inert atmosphere View Scheme
参考文献
Bigot, Aurelien; Williamson, Alice E.; Gaunt, Matthew J.
Journal of the American Chemical Society, 2011 , vol. 133, # 35 p. 13778 - 13781
