(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
adenylate kinase; pyruvate kinase; Phosphoenolpyruvate; recombinant Luciola lateralis luciferase; adenosine 5'-triphosphoric acid; Reduced nicotinamide-adenine dinucleotide; magnesium chloride; lactate dehydrogenase T=27°C; pH=7; aq. potassium phosphate bufferEnzymatic reaction; enantioselective reaction;
参考文献
Kato, Dai-Ichiro; Tatsumi, Tomohiro; Bansho, Asami; Teruya, Keisuke; Yoshida, Hiromitsu; Takeo, Masahiro; Negoro, Seiji
Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 69, # 3-4 p. 140 - 146
反应条件
1: Candida antarctica lipase B RG401 mutant; water / aq. phosphate buffer; acetonitrile / 16.5 h / 30 °C / pH 7.5 / |Resolution of racemate; |Enzymatic reaction 2: Candida antarctica lipase B SG303 mutant; water / aq. phosphate buffer / 25 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
Wu, Qi; Soni, Pankaj; Reetz, Manfred T.
Journal of the American Chemical Society, 2013 , vol. 135, # 5 p. 1872 - 1881
反应条件
1: tBuOOH, L-(+)-DIPT, Ti(OiPr)4 2: 100 percent / Swern oxidation 3: 76 percent 4: Et3SiH, BF3*Et2O 5: 94 percent / pyr 6: 1.) LiEt3BH, 2.) NaIO4/RuCl3*H2O / 1.) CH3CN; 2.) CCl4 View Scheme
参考文献
Jung, Michael E.; Anderson, Karen L.
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2605 - 2608
反应条件
1: Et3SiH, BF3*Et2O 2: 94 percent / pyr 3: 1.) LiEt3BH, 2.) NaIO4/RuCl3*H2O / 1.) CH3CN; 2.) CCl4 View Scheme
参考文献
Jung, Michael E.; Anderson, Karen L.
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2605 - 2608
反应条件
1: 94 percent / pyr 2: 1.) LiEt3BH, 2.) NaIO4/RuCl3*H2O / 1.) CH3CN; 2.) CCl4 View Scheme
参考文献
Jung, Michael E.; Anderson, Karen L.
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2605 - 2608
反应条件
in water Title compound not separated from byproducts;
参考文献
Yousefi, Maryam; Mohammadi, Mehdi; Habibi, Zohreh
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 104, p. 87 - 94
反应条件
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; zinc(II) chloride 1.) ether, THF, RT, 10 min, 2.) ether, THF, RT, 1.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hamon, David P.G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron, 1995 , vol. 51, # 46 p. 12645 - 12660
反应条件
TSP in phosphate buffer; water-d2 pH=7.4; Kinetics;
参考文献
Johnson, Caroline H.; Wilson, Ian D.; Harding, John R.; Stachulski, Andrew V.; Iddon, Lisa; Nicholson, Jeremy K.; Lindon, John C.
Analytical Chemistry, 2007 , vol. 79, # 22 p. 8720 - 8727
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Zhang, Aibin; RajanBabu
Organic Letters, 2004 , vol. 6, # 9 p. 1515 - 1517
反应条件
potassium permanganate; sodium periodate; lt;S-2-(dimethylamino)-3-phenylpropylgt;diphenylphosphinephe; nickel dichloride 1.) ether, a) -78 deg C, b) -20 deg C, 24 h, 2.) tert-butyl alcohol, water; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Pavlov, V. A.; Klabunovskii, E. I.; Zhorov, E. Yu.; Gorshkova, L. S.; Rodin, A. P.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 6.1 p. 1009 - 1018
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 6 p. 1121 - 1131
