(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
1: With ozone in acetone T=-78°C; 2: With chromium(VI) oxide; sulfuric acid in acetone T=-78 - 20°C; Jones oxidation;
参考文献
Harrington-Frost, Nicole; Leuser, Helena; Calaza, M. Isabel; Kneisel, Florian F.; Knochel, Paul
Organic Letters, 2003 , vol. 5, # 12 p. 2111 - 2114
反应条件
1: With (1R,2R)-(+)-1,2-diphenylethylenediamine; potassium tert-butylate; hydrogen; RuCl2 in tert-butyl alcohol; hexan-1-ol T=20°C; P=15001.5 Torr; 2: With potassium permanganate; sulfuric acid in acetone T=0°C; Further stages.;
参考文献
Li, Xiaoguang; List, Benjamin
Chemical Communications, 2007 , # 17 p. 1739 - 1741
反应条件
palladium on carbon; hydrogen in tetrahydrofuran T=20°C; P=760.051 Torr; 26 h; optical yield given as percent ee;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Onda, Yu-Suke; Itagaki, Makoto
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11629 - 11641
反应条件
Thermotoga maritima esterase Tm1160 in aq. acetate buffer T=70°C; pH=5.5; Enzymatic reaction; enantioselective reaction;
参考文献
Wei, Tao; Feng, Shengxue; Mao, Duobin; Yu, Xuan; Du, Congcong; Wang, Xihua
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 85-86, p. 23 - 30
参考文献
Koul, Surrinder; Koul, Jawahir Lal; Singh, Budh; Kapoor, Munish; Parshad, Rajinder; Manhas, Kuldeep S.; Taneja, Subhash C.; Qazi, Ghulam N.
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2575 - 2591
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C; 1 h;
参考文献
Akkari; Calmes; Mai; Rolland; Martinez
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5859 - 5865
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 1.5 h; Ambient temperature;
参考文献
Hamon, David P.G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron, 1995 , vol. 51, # 46 p. 12645 - 12660
反应条件
1: 94.7 percent / CH2Cl2 2: Trichosporon beigelli esterase / aq. phosphate buffer / 96 h / 29 °C / pH 8.0 View Scheme
参考文献
Fujiwara, Tomoya; Sasaki, Masaki; Omata, Kenji; Kabuto, Chizuko; Kabuto, Kuninobu; Takeuchi, Yoshio
Tetrahedron Asymmetry, 2004 , vol. 15, # 3 p. 555 - 563
反应条件
Jone's reagent; ozone in acetone T=-78°C;
参考文献
Beaulieu, Christian; Spino, Claude
Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1637 - 1640
反应条件
tin(IV) chloride; (R,R)-(-)-2-o-fluorobenzyloxy-1,2-bis[3,5-bis(trifluoromethyl)phenyl]ethanol in hexane; toluene T=-78°C; 1 h; Title compound not separated from byproducts.;
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
