(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
Ni(PCy3)2Cl2; tetra-(n-butyl)ammonium iodide; zinc in N,N-dimethyl acetamide T=20°C; P=760.051 Torr; Schlenk technique;
参考文献
Leon, Thierry; Correa, Arkaitz; Martin, Ruben
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1221 - 1224
反应条件
sodium hydroxide in ethanol; water
参考文献
Paradies; Henrich H.
Patent: US5248815 A1, 1993 ;
反应条件
sodium hydroxide in ethanol; water
参考文献
Paradies; Henrich H.
Patent: US5248815 A1, 1993 ;
反应条件
ruthenium trichloride; sodium periodate
参考文献
Hamon, David P.G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron, 1995 , vol. 51, # 46 p. 12645 - 12660
反应条件
lithium chloride in N,N-dimethyl-formamide 0.166667 h; Microwave irradiation; optical yield given as percent eeregioselective reaction;
参考文献
Wu, Xiao-Ai; Ying, Ping; Liu, Jun-Yang; Shen, Heng-Shui; Chen, Yue; He, Ling
Synthetic Communications, 2009 , vol. 39, # 19 p. 3459 - 3470
反应条件
hydrogenchloride; peracetic acid; sodium hydroxide; sodium thiosulfate in water; ethyl acetate
参考文献
Union Carbide Chemicals and Plastics Technology Corporation
Patent: US5739385 A1, 1998 ;
反应条件
EtOH, TAPS/Tris buffer, pH 7.7;
参考文献
Miyako, Eijiro; Maruyama, Tatsuo; Kamiya, Noriho; Goto, Masahiro
Journal of the American Chemical Society, 2004 , vol. 126, # 28 p. 8622 - 8623
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water
参考文献
Oppolzer, Wolfgang; Rosset, Stephane; De Brabander, Jef
Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1539 - 1540
反应条件
sodium hydroxide in water 3 h; Heating;
参考文献
Garot, C.; Javed, T.; Mason, T. J.; Turner, J. L.; Cooper, J. W.
Bulletin des Societes Chimiques Belges, 1996 , vol. 105, # 12 p. 755 - 758
反应条件
sodium hydroxide; Pseudomonas fluorescens MTCCB0015 cell-free extract in phosphate buffer T=37°C; pH=7.50; 20 h;
参考文献
Kumar, Ish; Manju, Kavita; Jolly, Ravinder S.
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1431 - 1434
