(S)-(+)-布洛芬合成路线 （共 120 条）
反应条件
hydrogenchloride; acetic acid T=85°C; Yield given. Yields of byproduct given;
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
反应条件
hydrogenchloride; acetic acid T=85°C;
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
反应条件
hydrogenchloride; acetic acid T=85°C;
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
反应条件
hydrogenchloride; acetic acid T=85°C; Yield given. Yields of byproduct given;
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
反应条件
hydrogenchloride; acetic acid T=85°C;
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
反应条件
air in ethanol; acetonitrile Irradiation;
参考文献
Ashraf, M. Arfan; Russell, Alexander G.; Wharton, Christopher W.; Snaith, John S.
Tetrahedron, 2007 , vol. 63, # 3 p. 586 - 593
反应条件
1.1: butyllithium / diethyl ether; hexane / 4 h / 20 °C 1.2: 41 percent / diethyl ether; hexane / 20 °C 2.1: AD-mix-α / 2-methyl-propan-2-ol; H2O 3.1: hydrogen / Pearlman's catalyst / ethanol / 6 h 4.1: CrO3; H2SO4 / acetone; H2O / 2 h / 20 °C View Scheme
参考文献
Nandanan; Jayachandran; Phukan, Prodeep; Pais, Godwin C. G.; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 12 p. 1221 - 1227
反应条件
1: AD-mix-α / 2-methyl-propan-2-ol; H2O 2: hydrogen / Pearlman's catalyst / ethanol / 6 h 3: CrO3; H2SO4 / acetone; H2O / 2 h / 20 °C View Scheme
参考文献
Nandanan; Jayachandran; Phukan, Prodeep; Pais, Godwin C. G.; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 12 p. 1221 - 1227
反应条件
1: 1.) ZnCl2, 2.) dichlorobis(triphenylphosphine)palladium(II), DIBALH / 1.) THF, RT, 10 min, 2.) THF, RT, 1.5 h 2: 69 percent / H2 / 10percent Pd/C / ethyl acetate / 1.5 h / Ambient temperature View Scheme
参考文献
Hamon, David P. G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron Letters, 1993 , vol. 34, # 33 p. 5333 - 5336
反应条件
1: 2.) 3-(dimethylamino)propylamine / 1.) toluene, -78 deg C, 2.) 25 deg C 2: CH3COOH, aq. HCl / 85 °C View Scheme
参考文献
Larsen; Corley; Davis; Reider; Grabowski
Journal of the American Chemical Society, 1989 , vol. 111, # 19 p. 7650 - 7651
