丁氧羰基-3 ,4-脱氢脯氨酸羟基合成路线 （共 26 条）
反应条件
1: cyclohexane 2: liquid ammonia / -78 °C 3: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: methanol 2: cyclohexane 3: liquid ammonia / -78 °C 4: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: Et3N / CH2Cl2 / 1 h / 0 °C 2: 85.5 kg / Et3N / CH2Cl2 / 0 °C 3: NaOC2H4OC2H4NMe2 / acetonitrile; toluene / 20 h / 20 °C View Scheme
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: liquid ammonia / -78 °C 2: 45 percent / aq. NaHCO3; Novozym(R) View Scheme
参考文献
Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
Synthesis, 2004 , # 14 p. 2367 - 2375
反应条件
1: (i-Pr)2NEt; LiCl / acetonitrile; hexane; CHCl3 / 3.5 h / -78 - -20 °C 2: 41 percent / DIBAL-H / toluene / 2 h / -78 - 0 °C 3: Et3N / tetrahydrofuran / 0.75 h / -78 - 0 °C 4: NaH / dimethylformamide / 0.75 h / 0 °C 5: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 6: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 7: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 2: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 °C 2: (i-Pr)2NEt; LiCl / acetonitrile; hexane; CHCl3 / 3.5 h / -78 - -20 °C 3: 41 percent / DIBAL-H / toluene / 2 h / -78 - 0 °C 4: Et3N / tetrahydrofuran / 0.75 h / -78 - 0 °C 5: NaH / dimethylformamide / 0.75 h / 0 °C 6: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 7: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 8: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 2: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 3: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: Et3N / tetrahydrofuran / 0.75 h / -78 - 0 °C 2: NaH / dimethylformamide / 0.75 h / 0 °C 3: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 4: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 5: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: 41 percent / DIBAL-H / toluene / 2 h / -78 - 0 °C 2: Et3N / tetrahydrofuran / 0.75 h / -78 - 0 °C 3: NaH / dimethylformamide / 0.75 h / 0 °C 4: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 5: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 6: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
