丁氧羰基-3 ,4-脱氢脯氨酸羟基合成路线 （共 26 条）
反应条件
1: NaH / dimethylformamide / 0.75 h / 0 °C 2: 74 percent / TBAF / tetrahydrofuran / 2.5 h / 0 °C 3: (COCl)2; DMSO; (i-Pr)2NEt / CHCl3; hexane / 1.5 h / -78 - 0 °C 4: NaClO2; NaH2PO4*2H2O; 2-methylbut-2-ene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C View Scheme
参考文献
Ishii, Kiyonori; Ohno, Hiroaki; Takemoto, Yoshiji; Osawa, Eriko; Yamaoka, Yumiko; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 15 p. 2155 - 2163
反应条件
1: 64 percent / 6 h / 170 - 180 °C / 12 Torr 2: 70 percent / 50percent NaOH / H2O; dioxane / 2 h View Scheme
参考文献
Dormoy, Jean-Robert; Castro, Bertrand; Chappuis, Georges; Fritschi, Ulrich-Stefan; Grogg, Peter
Angewandte Chemie, 1980 , vol. 92, # 9 p. 761
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 40-41 ;
反应条件
in diethyl ether T=-15 - 20°C;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2004/7501 A1, 2004 ;
Location in patent: Page 416-417 ;
WO 2004/007501 A1
反应条件
1: in methanol; hexane; toluene T=0°C; 0.75 h; 2: With acetic acid in methanol; hexane; toluene Product distribution / selectivity;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2007/17698 A1, 2007 ;
Location in patent: Page/Page column 30-31 ;
反应条件
potassium hydrogencarbonate in acetone T=30 - 45°C; 5.25 - 6.33333 h; Heating / reflux; Product distribution / selectivity;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2007/17698 A1, 2007 ;
Location in patent: Page/Page column 37-38 ;
