in PEG-400 T=20°C; 0.166667 h;

porcine liver esterase; ammonium sulfate; diethylenetriamine-N,N,N',N'',N''-pentaacetic acid in dimethyl sulfoxide T=37°C; pH=7.4; 120 h; Inert atmosphereaq. phosphate bufferEnzymatic reaction;

N-(N-L-γ-glutamyl-L-cysteinyl)glycine; diethylenetriamine-N,N,N',N'',N''-pentaacetic acid in dimethyl sulfoxide T=37°C; pH=7.4; 6.66667 h; Inert atmosphereaq. phosphate buffer;

hydrogenchloride in dichloromethane 5 h; Ambient temperature;

1: (3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester With NOBF4 in acetonitrile T=0°C; 0.333333 h; 2: isopropylamine in acetonitrile T=20°C;

iodine T=20°C; 1 h;

1: 77 percent / Bu3SnH; AIBN / benzene / 1 h / Heating View Scheme

1: tetrabutyl ammonium fluoride / dichloromethane / 2 h / 0 - 20 °C 2: N-(N-L-γ-glutamyl-L-cysteinyl)glycine; diethylenetriamine-N,N,N',N'',N''-pentaacetic acid / dimethyl sulfoxide / 6.67 h / 37 °C / pH 7.4 / Inert atmosphere; aq. phosphate buffer View Scheme

1.1: lithium tert-butylate / hexane / 0.33 h / 0 °C / Inert atmosphere 1.2: 0.33 h / 0 °C / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / dichloromethane / 2 h / 0 - 20 °C 3.1: N-(N-L-γ-glutamyl-L-cysteinyl)glycine; diethylenetriamine-N,N,N',N'',N''-pentaacetic acid / dimethyl sulfoxide / 6.67 h / 37 °C / pH 7.4 / Inert atmosphere; aq. phosphate buffer View Scheme

in chloroform-d1 24 h; Ambient temperatureother times; Product distribution;