3-羟基-2-噻吩甲酸甲酯合成路线 （共 43 条）
反应条件
sodium methylate in methanol T=25°C; Cyclization; 17 h;
参考文献
Plant; Harder; Mencke; Bertram
Pesticide Science, 1996 , vol. 48, # 4 p. 351 - 358
反应条件
sodium hydrogencarbonate in methanol T=10°C; Reflux;
参考文献
Savitha, Gurunathan; Hergue, Noemie; Guilmet, Erwan; Allain, Magali; Frere, Pierre
Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1288 - 1291
反应条件
sodium methylate in methanol; hexane
反应条件
sodium methylate in methanol T=25°C; Cyclization;
参考文献
Plant; Harder; Mencke; Bertram
Pesticide Science, 1996 , vol. 48, # 4 p. 351 - 358
反应条件
sulfuryl dichloride; triethylamine
参考文献
Rossy, Phillip A.; Hoffmann, Werner; Mueller, Norbert
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 617 - 620
反应条件
sodium methylate; benzene
参考文献
Chemische Berichte, , vol. 87, p. 848,855
反应条件
phosphorus pentachloride; sodium hydrogencarbonate in tetrachloromethane; water
参考文献
Hoffmann-La Roche Inc.
Patent: US4076709 A1, 1978 ;
反应条件
1: 34 percent / potassium carbonate / dimethylsulfoxide / 22 h / 100 °C / Irradiation; ultrasonic irradiation 2: 96 percent / hydrogen / palladium on charcoal (10percent) / methanol / 3102.9 Torr View Scheme
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2004/7517 A1, 2004 ;
Location in patent: Page/Page column 66 ;
反应条件
potassium carbonate in acetone Etherification; 12 h; Heating;
参考文献
Plant; Harder; Mencke; Bertram
Pesticide Science, 1996 , vol. 48, # 4 p. 351 - 358
