3-羟基-2-噻吩甲酸甲酯合成路线 （共 43 条）
反应条件
1: 98 percent / K2CO3 / acetone / 12 h / Heating 2: 80 percent / aq. NaOH / 2.5 h / Heating View Scheme
参考文献
Plant; Harder; Mencke; Bertram
Pesticide Science, 1996 , vol. 48, # 4 p. 351 - 358
反应条件
sulfuric acid; nitric acid T=-10 - 0°C;
参考文献
Journal of Chemical Research, Miniprint, , # 10 p. 1001 - 1023
反应条件
bromine in acetic acid Ambient temperature;
参考文献
Corral; Lissavetzky
Synthesis, 1984 , vol. NO. 10, p. 847 - 850
反应条件
hydrogenchloride; N-chloro-succinimide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
参考文献
WARNER-LAMBERT COMPANY
Patent: EP249236 B1, 1991 ;
反应条件
bromine in acetic acid T=20°C;
参考文献
Chao, Jianhua; Taveras, Arthur G.; Aki, Cynthia J.
Tetrahedron Letters, 2009 , vol. 50, # 35 p. 5005 - 5008
反应条件
1: N-chlorosuccinimide / acetic acid / 60 °C 2: 4 h / Ambient temperature View Scheme
参考文献
Corral, Carlos; Lissavetzky, Jaime
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2711 - 2714
反应条件
sodium hydroxide; potassium carbonate in methanol; dichloromethane; acetone; acetonitrile; Petroleum ether
参考文献
California Institute of Technology
Patent: US7452730 B2, 2008 ;
参考文献
Gronowitz
Arkiv foer Kemi, 1958 , vol. 12, p. 239,243
反应条件
potassium hydroxide in methanol; water
参考文献
Laevosan-Gesellschaft mbH and Co. KG
Patent: US4352819 A1, 1982 ;
反应条件
1: K2CO3 / acetone; acetonitrile / 3 h / Heating 2: 0.736 g / NaOH / methanol / 3 h View Scheme
参考文献
Foister, Shane; Marques, Michael A.; Doss, Raymond M.; Dervan, Peter B.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4333 - 4340
