3-羟基-2-噻吩甲酸甲酯合成路线 （共 43 条）
反应条件
potassium tert-butylate 1.) methanol, warming, 2.) DMF, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1829 - 1836
反应条件
1: 78 percent / 99percent N2H4*H2O / butan-1-ol / 4 h / Heating 2: 50 percent / 2M NaOH / 8 h / Heating View Scheme
参考文献
Barker, John M; Huddleston, Patrick R; Wood, Michael L
Journal of Chemical Research, Miniprint, 1992 , # 9 p. 2383 - 2396
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 0.5 h;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
1: 1.) potassium t-butoxide / 1.) methanol, warming, 2.) DMF, reflux, 3 h 2: 90 percent / iron powder, acetic acid / methanol / 1.25 h / Heating View Scheme
参考文献
Coutts, Ian G. C.; Culbert, Nicholas J.; Edwards, Mark; Hadfield, John A.; Musto, Donald R.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1829 - 1836
反应条件
1: bromine / acetic acid / 24 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 12 p. 1288 - 1291
反应条件
1: 96 percent / potassium carbonate / dimethylsulfoxide / 0.5 h / 100 °C 2: 92 percent / hydrogen / palladium on charcoal (10percent) / methanol / 3102.9 Torr View Scheme
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
1: 89 percent / 1) K2CO3 / acetone / 1) 10 min, 2) 5 h, reflux 2: 95 percent / 1M NaOH / Heating View Scheme
参考文献
Darias; Bravo; Abdallah; Sanchez Mateo; Exposito-Orta
Archiv der Pharmazie, 1992 , vol. 325, # 2 p. 83 - 87
反应条件
potassium carbonate in acetone 1) 10 min, 2) 5 h, reflux;
参考文献
Darias; Bravo; Abdallah; Sanchez Mateo; Exposito-Orta
Archiv der Pharmazie, 1992 , vol. 325, # 2 p. 83 - 87
反应条件
potassium carbonate in acetone; acetonitrile 3 h; Heating;
参考文献
ELI LILLY AND COMPANY; HAMDOUCHI, Chafiq; LINESWALA, Jayana, Pankaj; MAITI, Pranab
Patent: WO2011/66183 A1, 2011 ;
Location in patent: Page/Page column 14 ;
WO 2011/066183 A1
反应条件
sodium hydroxide; (benzyl)-tri-(butyl)-ammonium chloride in dichloromethane
参考文献
Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J.
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411
