3-羟基-2-噻吩甲酸甲酯合成路线 （共 43 条）
反应条件
1: 68 percent / sulphuryl chloride / CHCl3 / 4 h / Ambient temperature 2: 10 h / Ambient temperature View Scheme
参考文献
Corral, Carlos; Lissavetzky, Jaime
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2711 - 2714
反应条件
sulfuric acid; nitric acid
T=-10 - 0°C;
参考文献
Barker, John M.; Huddelston, Patrick R.; Wood, Michael L.; Burkitt, Simon A.
Journal of Chemical Research, Miniprint, 2001 , # 10 p. 1001 - 1023
反应条件
sulfuric acid; nitric acid
T=0°C; 3 h;
参考文献
Marques, Michael A.; Doss, Raymond M.; Urbach, Adam R.; Dervan, Peter B.
Helvetica Chimica Acta, 2002 , vol. 85, # 12 p. 4485 - 4517
反应条件
1: 1.) NaH / 1.) DMF; 2.) 80 deg C, 1 h
2: 83 percent / 0.5 h / 220 °C
3: 90 percent / aq. 10percent NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Corral, C.; Lissavetzky, J.; Valdeolmillos, A. M.
Synthesis, 1984 , # 2 p. 172
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 20 h;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 22 h; Irradiationultrasonic irradiation;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 20 h;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
potassium carbonate in dimethyl sulfoxide
T=100°C; 3 h;
参考文献
Corral; Lissavetzky; Valdeolmillos
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 5 p. 1349 - 1352
反应条件
sulfuryl dichloride in dichloromethane; chloroform
T=20°C; 4.03333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/75465 A1, 2005 ;
Location in patent: Page/Page column 29 ;
WO 2005/075465 A1
反应条件
1: 68 percent / sulphuryl chloride / CHCl3 / 4 h / Ambient temperature
2: 72 h / Ambient temperature
3: K2CO3 / acetone / 5 h / Heating
4: 1M NaOH / 0.5 h / Heating
View Scheme
参考文献
Corral, Carlos; Lissavetzky, Jaime
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2711 - 2714
