3-羟基-2-噻吩甲酸甲酯合成路线 （共 43 条）
反应条件
1: 68 percent / sulphuryl chloride / CHCl3 / 4 h / Ambient temperature
2: 10 h / Ambient temperature
3: K2CO3 / acetone / 5 h / Heating
4: 1M NaOH / 0.5 h / Heating
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参考文献
Corral, Carlos; Lissavetzky, Jaime
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2711 - 2714
反应条件
1: 99 percent / K2CO3 / dimethylformamide
2: aq. LiOH / tetrahydrofuran
View Scheme
参考文献
Corral; Lissavetzky
Synthesis, 1984 , vol. NO. 10, p. 847 - 850
反应条件
ammonia in methanol
T=60°C; 48 h;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2007/144637 A1, 2007 ;
Location in patent: Page/Page column 40 ;
WO 2007/144637 A1
