potassium hydride in tetrahydrofuran T=25°C; 19 h;

1: methylmagnesium bromide With copper(I) bromide dimethylsulfide complex in tetrahydrofuran T=0°C; 2: 2-(4-tert-butylcyclohexylidene)ethyl picolinate in tetrahydrofuran T=0°C; optical yield given as percent destereoselective reaction;

1: methylmagnesium bromide With copper(I) bromide dimethylsulfide complex; zinc dibromide in tetrahydrofuran T=0°C; 0.5 h; 2: 2-(4-tert-butylcyclohexylidene)ethyl picolinate in tetrahydrofuran T=0 - 20°C; optical yield given as percent destereoselective reaction;

(i) nBuLi, Et2O, pentane, (ii) /BRN= 507309/; Multistep reaction;