1: With n-butyllithium in tetrahydrofuran; hexane T=-80°C; 1 h; Inert atmosphere; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-80 - 20°C; 4 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane 2 h;

1: 1-bromo-3-phenylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran T=20°C; 2 h; Further stages.;

1: 1-bromo-3-phenylbenzene With n-butyllithium in diethyl ether; hexane; toluene T=-30 - 0°C; 1 h; 2: tri-isopropoxy-borane in diethyl ether; hexane; toluene T=-70 - 20°C; 1 h; 3: With hydrogenchloride; water in diethyl ether; hexane; toluene

diethyl ether T=-70°C; und anschliessenden Hydrolyse;

1.1: Pd(PPh3)4; Na2CO3 / 1,2-dimethoxy-ethane / 80 °C 2.1: n-BuLi / -78 °C 2.2: -78 - 20 °C 3.1: aq. HCl View Scheme

hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane BuLi soln. (hexane) addn. to biphenylbromide soln. (THF), mixt. stirring1 h, mixt. addn. to B-compd. soln. (THF) via canula (N2) at -78° C., stirring 1 h, gradual warming to room temp., aq. HCl addn., stirringat room temp. 15 h, solvent removal; under reduced pressure, Et2O addn., org. layer sepn., drying (MgSO4), soln. concn.. oil triturating with hexane, solid repptn. from MeOH/H2O;

1.1: Pd(PPh3)4; Na2CO3 / 1,2-dimethoxy-ethane / 80 °C 2.1: n-BuLi / -78 °C 2.2: -78 - 20 °C 3.1: aq. HCl View Scheme

tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide T=0°C; Suzuki-Miyaura Coupling; 5 h; Inert atmosphere;

Pd(1,2-bis(diphenylphosphino)ethane)Cl2; potassium carbonate in water; toluene T=70°C; Suzuki-Miyaura Coupling; 10 h;

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