(4-甲基-1,3-噻唑-2-基)甲胺合成路线 （共 5 条）
反应条件
hydrogen; palladium dihydroxide in ethyl acetate 5 h;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/042694 A1
反应条件
1: sodium tetrahydroborate; methanol / 0.75 h / 0 °C 2: triethylamine / dichloromethane / 0.33 h / 0 °C 3: sodium azide / N,N-dimethyl-formamide / 2 h / Reflux 4: hydrogen / palladium hydroxide on carbon / methanol View Scheme
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
WO 2012/054510 A1
反应条件
1: triethylamine / dichloromethane / 0.33 h / 0 °C 2: sodium azide / N,N-dimethyl-formamide / 2 h / Reflux 3: hydrogen / palladium hydroxide on carbon / methanol View Scheme
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
WO 2012/054510 A1
反应条件
1: sodium azide / N,N-dimethyl-formamide / 2 h / Reflux 2: hydrogen / palladium hydroxide on carbon / methanol View Scheme
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
WO 2012/054510 A1
参考文献
Goldberg; Kelly
Journal of the Chemical Society, 1947 , p. 1372,1374
