1-(4-甲基吡啶-3-基)乙酮合成路线 （共 18 条）
反应条件
hydrazine hydrate T=115 - 125°C; Erhitzen des erhaltenen Hydrazons mit Kaliumhydroxyd bis auf 180grad;
参考文献
Rabe; Jantzen
Chemische Berichte, 1921 , vol. 54, p. 926
反应条件
in water T=32°C; 96 h; dry baker's yeast;
参考文献
Rey; Szarek; MacLean
Canadian Journal of Chemistry, 1992 , vol. 70, # 12 p. 2922 - 2928
反应条件
sulfur in decalin
1 h; Heating / reflux;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2005/14566 A1, 2005 ;
Location in patent: Page/Page column 93 ;
反应条件
1: in diethyl ether
T=0 - 50°C;
2: With hydrogenchloride; water in diethyl ether
T=0°C;
参考文献
Takeda Chemical Industries, Ltd.; Kusaka, Masami
Patent: EP1348706 A1, 2003 ;
Location in patent: Page/Page column 37 ;
反应条件
hydrogenchloride; water in toluene
2 h;
参考文献
Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley Kwan Mung; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried Heinz; Romines III, William Henry; Wallace, Michael B.; Yang, Yi
Patent: US2003/225147 A1, 2003 ;
Location in patent: Page 35 ;
反应条件
1: 3-acetyl-pyridine With copper(l) iodide; dimethylsulfide in tetrahydrofuran
T=20°C;
2: With phenyl chloroformate in tetrahydrofuran
0.5 h;
3: methylmagnesium bromide With water; ammonium chloride; sulfur
more than 3 stages;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2003/72561 A1, 2003 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate in water; N,N-dimethyl-formamide
T=120°C; 2 h; Microwave irradiation;
2: With hydrogenchloride in water
T=20°C; 1 h;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; GANZHORM, Axel; MARCINIAK, Gilbert; MUZET, Nicolas; RONAN, Baptiste; VIVET, Bertrand; ZERR, Véronique
Patent: WO2013/190123 A1, 2013 ;
Location in patent: Page/Page column 67; 68 ;
反应条件
manganese(IV) oxide in toluene
72 h; Heating;
参考文献
Hilgeroth, Andreas; Brachwitz, Kristin; Baumeister, Ute
Heterocycles, 2001 , vol. 55, # 4 p. 661 - 669
反应条件
1: concentrated H2SO4
2: sodium ethylate; benzene / Erwaermen des Reaktionsprodukts mit wss.Salzsaeure
View Scheme
参考文献
Webb; Corwin
Journal of the American Chemical Society, 1944 , vol. 66, p. 1456,1458
反应条件
perchloric acid in 1,4-dioxane
参考文献
Brachwitz, Kristin; Voigt, Burkhardt; Meijer, Laurent; Lozach, Olivier; Schaechtele, Christoph; Molnar, Josef; Hilgeroth, Andreas
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 876 - 879
