N-邻苯二甲酰基-L-苯丙氨酸合成路线 （共 20 条）
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 °C 2.1: palladium diacetate; CuF2; N,N'-dimethyl-N,N'-propyleneurea / acetone / 24 h / 100 °C / |Inert atmosphere; |Schlenk technique 3.1: sodium nitrite; acetic acid / acetic anhydride / 48.5 h / -15 °C 3.2: 2 h / -15 °C 3.3: 2 h / 0 °C View Scheme
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
反应条件
hydrogenchloride; water in acetonitrile T=25°C; pH=7.25; Kinetics; ConcentrationpH-valueReagent/catalystSolvent;
参考文献
Mathew, Beena; Deepthi
Asian Journal of Chemistry, 2013 , vol. 25, # 4 p. 1985 - 1990
反应条件
1: (COCl)2 2: 2.) H3O(+) / 1.) 90 deg C 4: NaBH4 6: p-TsOH, EtOH 7: t-BuOK 8: dimethylformamide / 120 °C 9: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
1: (COCl)2 2: 2.) H3O(+) / 1.) 90 deg C 4: NaBH4 6: p-TsOH, EtOH 7: t-BuOK 8: dimethylformamide / 120 °C 9: 1.) MeNH2, 2.) HCl 11: H2 / Pd/C View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
in acetonitrile T=20°C; 24 h; Irradiation; Product distribution;
参考文献
Griesbeck; Henz; Hirt; Ptatschek; Engel; Loffler; Schneider
Tetrahedron, 1994 , vol. 50, # 3 p. 701 - 714
反应条件
in acetonitrile
T=20°C; 24 h; Irradiation; Product distribution;
参考文献
Griesbeck; Henz; Hirt; Ptatschek; Engel; Loffler; Schneider
Tetrahedron, 1994 , vol. 50, # 3 p. 701 - 714
反应条件
1: (COCl)2
2: 2.) H3O(+) / 1.) 90 deg C
4: NaBH4
6: p-TsOH, EtOH
7: t-BuOK
8: dimethylformamide / 120 °C
9: 1.) MeNH2, 2.) HCl
View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
1: benzene; phosphorus (V)-chloride
2: triethylamine; dichloromethane / -45 °C
3: water; acetone; hydrochloric acid
4: ethanol; N2H4+H2O
View Scheme
参考文献
Sheehan; Bloom
Journal of the American Chemical Society, 1952 , vol. 74, p. 3825,3827
反应条件
in acetone
3 h; Irradiation;
参考文献
Sato, Yasuhiko; Nakai, Hideo; Mizoguchi, Tomishige; Kawanishi, Masazumi; Hatanaka, Yasumaru; Kanaoka, Yuichi
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1263 - 1270
反应条件
in acetonitrile
T=20°C; 24 h; Irradiation; Product distribution;
参考文献
Griesbeck; Henz; Hirt; Ptatschek; Engel; Loffler; Schneider
Tetrahedron, 1994 , vol. 50, # 3 p. 701 - 714
