3,4-二甲氧基-2-甲基苯甲醛合成路线 （共 21 条）
反应条件
chloroform; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane
beim Erwaermen des Reaktionsprodukts mit wss. Essigsaeure;
参考文献
Burger; Foggio
Journal of the American Chemical Society, 1956 , vol. 78, p. 4419,4422
反应条件
1: 70 percent / polyphosphoric acid / 1.5 h / 45 - 50 °C
2: 81.5 percent / aq. NaOCl / 0.67 h / 60 - 70 °C
3: 74 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating
4: 88 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Borchardt, Ronald T.; Bhatia, Pramila
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 263 - 271
反应条件
1: 81.5 percent / aq. NaOCl / 0.67 h / 60 - 70 °C
2: 74 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating
3: 88 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Borchardt, Ronald T.; Bhatia, Pramila
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 263 - 271
反应条件
1: 83 percent / K2CO3 / acetone / 3 h / Heating
2: 70 percent / polyphosphoric acid / 1.5 h / 45 - 50 °C
3: 81.5 percent / aq. NaOCl / 0.67 h / 60 - 70 °C
4: 74 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating
5: 88 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Borchardt, Ronald T.; Bhatia, Pramila
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 263 - 271
反应条件
1: BCl3*SMe2 / 1,2-dichloro-ethane / 83 °C
2: NaOH / H2O / 100 °C
View Scheme
参考文献
Buszek, Keith R.; Bixby, Dale L.
Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9129 - 9132
反应条件
1: 2,2,6,6-tetramethylpiperidinyl-lithium
2: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
参考文献
Perkin
Journal of the Chemical Society, 1916 , vol. 109, p. 828,831
Journal of the Chemical Society, 1919 , vol. 115, p. 713
反应条件
aluminium trichloride; benzene
anschliessend Behandeln des Reaktionsgemisches mit HCl;
参考文献
Cromartie; Harley-Mason
Journal of the Chemical Society, 1952 , p. 1052
参考文献
Perkin
Journal of the Chemical Society, 1918 , vol. 113, p. 764
反应条件
water; boron tribromide in dichloromethane
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2006/83417 A2, 2006 ;
Location in patent: Example 5 ;
