2-苯基-6-苯并恶唑乙酸乙酯合成路线 （共 13 条）
参考文献
Lilly Industries, Ltd.
Patent: US3962441 A1, 1976 ;
反应条件
1: polyphosphoric acid / 0.33 h / 180 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: aq. H2SO4 / 1.5 h / Heating
2: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: 0.33 h / 200 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: NBS / CCl4 / 3 h / Heating; Irradiation
2: DMF / 7 h / Ambient temperature
3: aq. H2SO4 / 1.5 h / Heating
4: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: polyphosphoric acid / 0.33 h / 180 - 210 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: (i) Py, (ii) (heating)
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: DMF / 7 h / Ambient temperature
2: aq. H2SO4 / 1.5 h / Heating
3: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: 0.33 h / 220 °C
2: NBS / CCl4 / 3 h / Heating; Irradiation
3: DMF / 7 h / Ambient temperature
4: aq. H2SO4 / 1.5 h / Heating
5: TsOH / benzene / 24 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
toluene-4-sulfonic acid in benzene
24 h; Heating;
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
