2-苯基-6-苯并恶唑乙酸乙酯合成路线 （共 13 条）
反应条件
1: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
2: LiAlH4 / diethyl ether / Ambient temperature
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: (i) NaNH2, liq. NH3, Et2O, (ii) /BRN= 969135/
2: aq. HCl / 6 h / Heating
View Scheme
参考文献
Dunwell,D.W.; Evans,D.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=10°C; 2 h;
2: With water; sodium hydroxide in tetrahydrofuran
参考文献
NEWLINK GENETICS; MAUTINO, Mario, R.; KUMAR, Sanjeev; JAIPURI, Firoz; WALDO, Jesse; KESHARWANI, Tanay; ZHANG, Xiaoxia
Patent: WO2011/56652 A1, 2011 ;
Location in patent: Page/Page column 136 ;
WO 2011/056652 A1
