N-Boc-9-氮杂双环[3.3.1]壬烷-3-酮合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran T=15 - 20°C;
参考文献
WO2009/98209 A1, ;
Page/Page column 16 ;
反应条件
1: pseudopelletierine hydrochloride With N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane T=0°C; 1 h; 2: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=80°C; 8 h; 3: di-tert-butyl dicarbonate With methanol; potassium carbonate more than 3 stages;
参考文献
WO2006/97292 A1, ;
Page/Page column 36-37 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C;
参考文献
WO2006/92268 A1, ;
Page/Page column 28 ;
WO 2006/092268 A1
反应条件
1: pseudopelletierine hydrochloride With N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane T=0°C; 1 h; 2: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=80°C; 8 h; 3: di-tert-butyl dicarbonate With methanol; potassium carbonate more than 3 stages;
参考文献
WO2006/97293 A2, ;
Page/Page column 38-39 ;
反应条件
1: 3-methyl-3-aza-bicyclo[3.3.1]nonan-9-one oxalate With sodium hydroxide; water pH=11; 2: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=0 - 80°C; 3: di-tert-butyl dicarbonate With methanol; potassium carbonate more than 3 stages;
参考文献
WO2006/97293 A2, ;
Page/Page column 40-41 ;
反应条件
hydrogenchloride; water in 1,4-dioxane; dichloromethane T=20°C; 2 h;
参考文献
Kubas, Holger; Meyer, Udo; Hechenberger, Mirko; Klein, Kai-Uwe; Plitt, Patrick; Zemribo, Ronalds; Spexgoor, Harm W.; Van Assema, Sander G.A.; Abel, Ulrich
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6370 - 6376
