4-(4-氯苯基)-1,2,3,6-四氢吡啶盐酸盐合成路线 （共 8 条）
反应条件
1: Mg / tetrahydrofuran 2: 50percent aq. HCl / Heating View Scheme
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
1: Mg / tetrahydrofuran 2: 1.) H2, 2.) 50percent HCl / 1.) Pd/C / 1.) H2O, 2.) H2O, reflux View Scheme
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal 1.) H2O, 2.) H2O, reflux; Multistep reaction;
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
1: Mg / tetrahydrofuran 2: 50percent aq. HCl / Heating View Scheme
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
hydrogenchloride Heating;
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
反应条件
sodium hydroxide in water
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 167; 168 ;
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide
T=45°C; 48 h;
参考文献
Nicolaou; Mathison, Casey J. N.; Montagnon, Tamsyn
Journal of the American Chemical Society, 2004 , vol. 126, # 16 p. 5192 - 5201
反应条件
1.1: 95 percent / K2CO3 / acetone / Heating
2.1: 79 percent / mCPBA / CH2Cl2 / 18 h
3.1: 90 percent / BF3*Et2O / diethyl ether / 5 h / Heating
4.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C
4.2: 71 percent / tetrahydrofuran / 2 h / -78 °C
5.1: 93.2 percent / aq. HCl / tetrahydrofuran / 20 °C
6.1: 56 percent / NaBH4 / ethanol / 3 h / 0 °C
7.1: aq. NaOH / ethanol / 17 h / Heating
View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
