4-(2-氟-4-溴苯基)吗啉合成路线 （共 6 条）
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; 0.166667 h; 2: With copper(I) bromide in water T=0°C; Sandmeyer reaction; 2.66667 h; Reflux;
参考文献
Moran-Ramallal, Roberto; Liz, Ramon; Gotor, Vicente
Organic Letters, 2008 , vol. 10, # 10 p. 1935 - 1938
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=80°C; 1 h;
参考文献
Larsen, Simon Birkso; Bang-Andersen, Benny; Johansen, Tommy Norskov; Jorgensen, Morten
Tetrahedron, 2008 , vol. 64, # 13 p. 2938 - 2950
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
参考文献
Antane, Schuyler; Caufield, Craig E.; Hu, William; Keeney, David; Labthavikul, Pornpen; Morris, Koi; Naughton, Shaughnessy M.; Petersen, Peter J.; Rasmussen, Beth A.; Singh, Guy; Yang, Youjun
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 176 - 180
反应条件
1: 85 percent / copper(I) iodide; potassium carbonate; (+/-)-trans-1,2-diaminocyclohexane / dioxane / 15 h / 110 °C 2: 80 percent / pyridinium p-toluenesulfonate / ethanol / 0.5 h / Heating 3: triethylamine / CH2Cl2 / 1 h / 0 - 25 °C View Scheme
参考文献
Mallesham; Rajesh; Reddy, P Rajamohan; Srinivas; Trehan, Sanjay
Organic letters, 2003 , vol. 5, # 7 p. 963 - 965
反应条件
copper(l) iodide; potassium carbonate; 1,2-diamino-cyclohexane in 1,4-dioxane T=110°C; 23 h;
参考文献
Tetrahedron Letters, , vol. 49, # 19 p. 3060 - 3062
反应条件
copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane; potassium carbonate in 1,4-dioxane T=110°C; Goldberg Reaction; 20 h; Inert atmosphere;
参考文献
Li, Yan-Wu; Liu, Yan; Jia, Yun-Can; Yuan, Jian-Yong
Chinese Chemical Letters, 2013 , vol. 24, # 3 p. 230 - 232
