4-(2-氨基乙基)-1-羟基-2-磺基氧基-苯合成路线 （共 13 条）
反应条件
1: 13 percent / NaHCO3 / ethanol / 16 h / Heating
2: 1.) NaH, 2.) Me3N*SO3 / DMF, 1.) 30 min, room temp., 2.) 30 min
3: H2 / 10 percent Pd/C / ethanol / 0.5 h / 2280.2 - 3037.7 Torr
View Scheme
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
反应条件
1: 1.) NaH, 2.) Me3N*SO3 / DMF, 1.) 30 min, room temp., 2.) 30 min
2: H2 / 10 percent Pd/C / ethanol / 0.5 h / 2280.2 - 3037.7 Torr
View Scheme
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: triethylamine / dimethylformamide / 4 h / ice bath
2: tert-BuOK / dimethylformamide / 6 h
3: pyridine-sulfur trioxide complex / tetrahydrofuran / 14 h
4: 1.5 mg / ammonium formate, acetic acid / 10 percent Pd/C / methanol / 1 h
View Scheme
参考文献
Konishi-Imamura; Kim; Kobashi
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2994 - 2998
反应条件
1: H2, liq. NH3 / Raney-Co / 88260.9 Torr
2: ClSO3H, Py / CHCl3
3: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: NaBH4 / methanol
2: SOCl2
3: dimethylformamide
4: KOH / methanol
5: H2, liq. NH3 / Raney-Co / 88260.9 Torr
6: ClSO3H, Py / CHCl3
7: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: KOH / methanol
2: H2, liq. NH3 / Raney-Co / 88260.9 Torr
3: ClSO3H, Py / CHCl3
4: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: SOCl2
2: dimethylformamide
3: KOH / methanol
4: H2, liq. NH3 / Raney-Co / 88260.9 Torr
5: ClSO3H, Py / CHCl3
6: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: dimethylformamide
2: KOH / methanol
3: H2, liq. NH3 / Raney-Co / 88260.9 Torr
4: ClSO3H, Py / CHCl3
5: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
反应条件
1: ClSO3H, Py / CHCl3
2: H2 / Pd-C / aq. ethanol
View Scheme
参考文献
Hegedues,B.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2604 - 2612
