4-(2-氨基乙基)-1-羟基-2-磺基氧基-苯合成路线 （共 13 条）
反应条件
1: 2 N NaOH / toluene; H2O / 2 h / 5 - 10 °C
2: 13 percent / NaHCO3 / ethanol / 16 h / Heating
3: 1.) NaH, 2.) Me3N*SO3 / DMF, 1.) 30 min, room temp., 2.) 30 min
4: H2 / 10 percent Pd/C / ethanol / 0.5 h / 2280.2 - 3037.7 Torr
View Scheme
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
反应条件
sodium phosphate buffer; recombinant human sulfotransferase 1A3
T=37°C; 0.166667 h; Enzyme kinetics;
参考文献
Itaeaho, Katriina; Alakurtti, Sami; Yli-Kauhaluoma, Jari; Taskinen, Jyrki; Coughtrie, Michael W.H.; Kostiainen, Risto
Biochemical Pharmacology, 2007 , vol. 74, # 3 p. 504 - 510
反应条件
sulfuric acid
T=0°C; 0.116667 h; Product distribution;
参考文献
Jain, Tikam; Kaiser, Carl; Ackerman, Dennis M.; Ladd, David L.; Fong, Kei-Lai; et al.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 2418 - 2422
