(E)-乙基4-溴-3-甲基-2-丁烯酸酯合成路线 （共 19 条）
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile T=25°C; 1 h;
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Sandoz Ltd.
Patent: US4661617 A1, 1987 ;
反应条件
tetrachloromethane; N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile 3 h; Reflux;
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 447 - 455
反应条件
1: (COCl)2; DMF / CH2Cl2 / 1.5 h / 20 °C 2: -78 °C View Scheme
参考文献
Bandini, Marco; Melloni, Alfonso; Piccinelli, Fabio; Sinisi, Riccardo; Tommasi, Simona; Umani-Ronchi, Achille
Journal of the American Chemical Society, 2006 , vol. 128, # 5 p. 1424 - 1425
反应条件
1: 72 percent / H2SO4 / 10 h / Heating 2: NBS; AIBN / CCl4 / 3 h / Heating View Scheme
参考文献
Roeder, Erhard; Wiedenfeld, Helmut; Frisse, Manfred
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 9 p. 803 - 806
参考文献
Bandini, Marco; Melloni, Alfonso; Piccinelli, Fabio; Sinisi, Riccardo; Tommasi, Simona; Umani-Ronchi, Achille
Journal of the American Chemical Society, 2006 , vol. 128, # 5 p. 1424 - 1425
反应条件
T=165 - 170°C; 0.0833333 h;
参考文献
Mata, Ernesto G.; Thomas, Eric J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 7 p. 785 - 800
反应条件
1.1: 100 - 150 °C / Neat (no solvent) 2.1: N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / 0 °C / Horner-Wadsworth-Emmons reaction 2.2: -78 - 0 °C 3.1: water; sodium hydroxide / methanol; dimethyl sulfoxide / 2 h / 65 °C 3.2: 0 °C / pH 5 View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
1: NaOMe / methanol 2: KOtBu / tetrahydrofuran 3: Na-Hg / ethanol View Scheme
参考文献
Julia,M.; Arnould,D.
Bulletin de la Societe Chimique de France, 1973 , p. 743 - 746
反应条件
1: 42 percent / H2SO4 / H2O 2: 45 percent / various solvent(s) / 15 h / Heating View Scheme
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 447 - 455
