(E)-乙基4-溴-3-甲基-2-丁烯酸酯合成路线 （共 19 条）
反应条件
sulfuric acid in water
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 447 - 455
参考文献
Bittner,S. et al.
Phytochemistry (Elsevier), 1977 , vol. 16, p. 1143 - 1151
反应条件
1: 51 percent 2: 1.) KOH, 18-crown-6-ether / 1) benzene; 2) benzene, 20 deg C, 2 - 3 h View Scheme
参考文献
Kryshtal', G. V.; Serebryakov, E. P.; Suslova, L. M.; Yanovskaya, L. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 6 p. 1277 - 1279
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 6 p. 1414 - 1417
反应条件
(i) Zn, HgI2, (ii) (hydrolysis); Multistep reaction;
参考文献
Couffignal,R.; Gaudemar,M.
Journal of Organometallic Chemistry, 1975 , vol. 96, p. 149 - 162
反应条件
1.1: 100 - 150 °C / Neat (no solvent)
2.1: N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / 0 °C / Horner-Wadsworth-Emmons reaction
2.2: -78 - 0 °C
3.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 1 h / 0 - 25 °C
4.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 1 h / 25 °C
View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
反应条件
barium carbonate in 1,4-dioxane; water
Heating;
参考文献
Young, H.; Letham, D. S.; Hocart, C. H.; Eichholzer, J. V.
Phytochemistry (Elsevier), 1990 , vol. 29, # 2 p. 385 - 386
反应条件
1.1: 100 - 150 °C / Neat (no solvent)
2.1: N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium / tetrahydrofuran; hexanes / 0.67 h / 0 °C / Horner-Wadsworth-Emmons reaction
2.2: -78 - 0 °C
3.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 1 h / 0 - 25 °C
4.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 1 h / 25 °C
View Scheme
参考文献
Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 721 - 737
参考文献
Kryshtal', G. V.; Serebryakov, E. P.; Suslova, L. M.; Yanovskaya, L. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 10 p. 2142 - 2146
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 10 p. 2377 - 2382
反应条件
in diethyl ether
Heating;
参考文献
Kozlowska,M.; Sobotka,W.
Polish Journal of Chemistry, 1978 , vol. 52, p. 347 - 352
