[4-(哌嗪-1-基)苯基]硼酸合成路线 （共 3 条）
反应条件
tetrahydroxydiboron; [1,3-bis(diphenylphosphino) propane] dichloronickel(II); N-ethyl-N,N-diisopropylamine; triphenylphosphine in ethanol
T=80°C; Miyaura Borylation Reaction; 8 h; Inert atmosphereSealed tube;
参考文献
Molander, Gary A.; Cavalcanti, Livia N.; Garcia-Garcia, Carolina
Journal of Organic Chemistry, 2013 , vol. 78, # 13 p. 6427 - 6439
反应条件
1.1: n-BuLi / tetrahydrofuran; toluene; hexane / 0.33 h / -70 - -60 °C
1.2: triisopropyl borate / tetrahydrofuran; toluene; hexane / -70 - 0 °C
1.3: 92 percent / H3PO4; H2O / tetrahydrofuran; toluene; hexane / 0.5 h
2.1: 86 percent / HCl / ethyl acetate; dioxane / 6 h / 20 °C
3.1: NaOH
View Scheme
参考文献
Chen, Cheng-yi; Dagneau, Philippe; Grabowski, Edward J.J.; Oballa, Renata; O'Shea, Paul; Prasit, Peppi; Robichaud, Joel; Tillyer, Rich; Wang, Xin
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2633 - 2638
反应条件
1: 86 percent / HCl / ethyl acetate; dioxane / 6 h / 20 °C
2: NaOH
View Scheme
参考文献
Chen, Cheng-yi; Dagneau, Philippe; Grabowski, Edward J.J.; Oballa, Renata; O'Shea, Paul; Prasit, Peppi; Robichaud, Joel; Tillyer, Rich; Wang, Xin
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2633 - 2638
