1-[5-(4-氯苯基)-2-噻吩]-1-乙酮合成路线 （共 10 条）
反应条件
1: 4-chlorophenyl-magnesium bromide With bismuth(III) chloride 2: 1-(5-bromo-thien-2-yl)ethanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: 4-chlorophenyl-magnesium bromide With bismuth(III) chloride 2: 1-(5-iodothiophen-2-yl)ethanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: 4-chloro-aniline With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 2: 2-acetyl-thiophene With CuCl2·2H2O in water; acetone Meerwein arylation;
参考文献
Matiychuk; Obushak; Lytvyn; Horak, Yu. I.
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 1 p. 50 - 55
反应条件
1: aqueous hydrochloric acid; sodium nitrite; aq. NaOH solution 2: aluminium chloride; carbon disulfide View Scheme
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
反应条件
carbon disulfide; aluminium trichloride
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
反应条件
alkaline aqueous sodium hypobromite solution
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
反应条件
1: 70percent HClO4, Tl(NO3)3 / Ambient temperature
2: 95 percent / NH3 / methanol / 96 h / Ambient temperature
View Scheme
参考文献
Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714
反应条件
perchloric acid; thallium(III) nitrate
Ambient temperature;
参考文献
Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714
反应条件
1: 70percent HClO4, Tl(NO3)3 / Ambient temperature
2: 95 percent / NH3 / methanol / 96 h / Ambient temperature
3: 51 percent / t-BuOK / dimethylformamide / Ambient temperature
View Scheme
参考文献
Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714
