4-(吡啶-2-基氧基)苯甲酸合成路线 （共 6 条）
参考文献
Shionogi and Co., Ltd.
Patent: US3940403 A1, 1976 ;
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 20°C;
2: With hydrogenchloride in water
T=0°C; 0.5 h;
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: EP1348698 A1, 2003 ;
Location in patent: Page/Page column 25 ;
反应条件
1: With sodium hydroxide; ethanol; water
T=20°C; 3 h;
2: With hydrogenchloride
pH=3 - 4;
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: EP1348698 A1, 2003 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With methanol; sodium hydroxide; water in acetone
T=20°C; 5 h;
2: With hydrogenchloride; water
pH=3;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1748048 A1, 2007 ;
Location in patent: Page/Page column 47 ;
反应条件
1: potassium carbonate / 150 - 160 °C
2: ethanolic KOH-solution
View Scheme
参考文献
Hill; McGraw
Journal of Organic Chemistry, 1949 , vol. 14, p. 783,785
反应条件
1: potassium carbonate / 150 - 160 °C
2: ethanolic KOH-solution
View Scheme
参考文献
Hill; McGraw
Journal of Organic Chemistry, 1949 , vol. 14, p. 783,785
