5-溴-2,1,3-苯并恶唑合成路线 （共 14 条）
反应条件
triethyl phosphite in ethanol T=60°C; 1 h; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.
Patent: WO2009/158393 A1, 2009 ;
Location in patent: Page/Page column 100 ;
反应条件
triphenylphosphine in anhydrous xylene T=140°C; 4 h; Inert atmosphere;
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
triethyl phosphite in ethanol T=70 - 75°C; 2 h; Inert atmosphere;
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
1.1: KOH / ethanol / 1 h / 60 °C 1.2: aq. NaOCl / 1 h / 0 °C 2.1: PPh3 / xylene / 3 h / 140 °C View Scheme
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
1.1: 93 percent / N-bromosuccinimide; AcOH / 2 h / 60 °C 2.1: KOH / ethanol / 1 h / 60 °C 2.2: aq. NaOCl / 1 h / 0 °C 3.1: PPh3 / xylene / 3 h / 140 °C View Scheme
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
1: With sodium azide in ethylene glycol T=100 - 110°C; 2: With sodium azide in ethylene glycol T=60 - 120°C; 3 h;
参考文献
Vasil'ev; Struchkova; Sheremetev; Levinson; Varganov; Lyssenko
Russian Chemical Bulletin, 2011 , vol. 60, # 11 p. 2306 - 2314
Izv. Akad. Nauk, Ser. Khim., 2011 , # 11 p. 2262 - 2269,8
反应条件
1: 89 percent / NOBF4 / acetonitrile / 0.42 h / -15 °C 2: 90 percent / acetonitrile / 20 h / 0 °C View Scheme
参考文献
Lipilin, Dmitry L.; Smirnov, Oleg Yu.; Churakov, Aleksandr M.; Strelenko, Yuri A.; Ioffe, Sema L.; Tartakovsky, Vladimir A.
European Journal of Organic Chemistry, 2002 , # 20 p. 3435 - 3446
参考文献
Tappi; Forni
Annali di Chimica Applicata, 1949 , vol. 39, p. 338,342
反应条件
in N,N-dimethyl-formamide T=140°C; 24 h; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.
Patent: WO2009/158393 A1, 2009 ;
Location in patent: Page/Page column 100-101 ;
反应条件
in N,N-dimethyl acetamide T=160 - 170°C;
参考文献
Pilgram,K.; Zupan,M.
Journal of Heterocyclic Chemistry, 1974 , vol. 11, p. 813 - 814
