5-溴-2,1,3-苯并恶唑合成路线 （共 14 条）
反应条件
n-butyllithium; boron triethoxide; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; pentane T=-100°C; 0.0833333 h;
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-90 - -80°C; 0.25 h; Inert atmosphere;
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
1: 45 percent / n-BuLi; TMEDA; B(OEt)3 / tetrahydrofuran; pentane / 0.08 h / -100 °C
2: Pd(dba)2; P(o-tol)3; 2 N aq. Na2CO3 / dimethylformamide; toluene / 3 h / 110 °C
3: 40 percent / NaNO2 / dimethylformamide / 3 h / 20 °C
4: 68 percent / Pd(dba)2; PPh3; 2 N aq. Na2CO3 / dimethylformamide / 2 h / 80 °C
View Scheme
参考文献
Hersperger, Rene; Dawson, Janet; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 233 - 235
反应条件
1: Br2, Fe / 85 - 90 °C
2: dimethylformamide / 135 - 140 °C
View Scheme
参考文献
Pilgram,K.; Zupan,M.
Journal of Heterocyclic Chemistry, 1974 , vol. 11, p. 813 - 814
