N-甲基-2-(2-氨乙基)-吡咯烷合成路线 （共 2 条）
反应条件
1: 55 percent / diethyl ether / 20 h
2: 51 percent / ethanol / 3 h / Heating
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参考文献
Elslager; Hess; Johnson; Ortwine; Chu; Werbel
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 127 - 140
反应条件
1.1: ethanol; water / 0.5 h / 65 °C / Inert atmosphere; Industry scale
2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.75 h
2.2: 1.17 h
View Scheme
参考文献
SANOFI; ELENBAAS, Steven
Patent: WO2011/109675 A2, 2011 ;
