5-溴-2-氟甲苯合成路线

参考文献

Slade, David J.; Pelz, Nicholas F.; Bodnar, Wanda; Lampe, John W.; Watson, Paul S.
Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6331 - 6334

108-30-5丁二酸酐+

51437-00-45-溴-2-氟甲苯

349-22-44-(4-氟-3-甲基-苯基)-4-氧代-丁酸

参考文献

PanThera Biopharma, LLC
Patent: US2010/286125 A1, 2010 ;
Location in patent: Page/Page column 15 ;

51437-00-45-溴-2-氟甲苯

99725-13-05-溴-2-氟苄胺.盐酸盐

参考文献

Stokker, G. E.; Alberts, A. W.; Anderson, P. S.; Cragoe, E. J.; Deana, A. A.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 170 - 181

51437-00-45-溴-2-氟甲苯

99725-12-92-氟-5-溴溴苄

参考文献

STERIX LIMITED
Patent: WO2007/68905 A1, 2007 ;
Location in patent: Page/Page column 113-114 ;

2094-98-61,1′-偶氮双(环己烷甲腈)+

51437-00-45-溴-2-氟甲苯

99725-12-92-氟-5-溴溴苄

参考文献

Sumitomo Chemical Company, Limited
Patent: US6489487 B1, 2002 ;

51437-00-45-溴-2-氟甲苯+

122-51-0原甲酸三乙酯

135427-08-64-氟-3-甲基苯甲醛

参考文献

Fujisawa Pharmaceutical Co. Ltd.
Patent: US2006/14948 A1, 2006 ;
Location in patent: Page/Page column 25 ;
US 20060014948 A1

135427-08-64-氟-3-甲基苯甲醛

参考文献

Bayer Aktiengesellschaft
Patent: US6462242 B1, 2002 ;

51437-00-45-溴-2-氟甲苯+

68-12-2N,N-二甲基甲酰胺

135427-08-64-氟-3-甲基苯甲醛

参考文献

Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Xu, Xiang D.; Koszyk, Francis J.; Collins, Paul W.; Koboldt, Carol M.; Veenhuizen, Amy W.; Perkins, William E.; Casier, Jacquelen J.; Masferrer, Jaime L.; Zhang, Yan Y.; Gregory, Susan A.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1634 - 1647

5419-55-6硼酸三异丙酯+

51437-00-45-溴-2-氟甲苯

139911-27-64-氟-3-甲基苯硼酸

参考文献

Abbott Laboratories
Patent: US6307047 B1, 2001 ;

51437-00-45-溴-2-氟甲苯

185147-08-44-氟-3-甲基苯腈

参考文献

Khanna, Ish K.; Weier, Richard M.; Yu, Yi; Xu, Xiang D.; Koszyk, Francis J.; Collins, Paul W.; Koboldt, Carol M.; Veenhuizen, Amy W.; Perkins, William E.; Casier, Jacquelen J.; Masferrer, Jaime L.; Zhang, Yan Y.; Gregory, Susan A.; Seibert, Karen; Isakson, Peter C.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1634 - 1647