sulfuric acid

sulfuric acid

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C 2: sodium hydroxide; water / methanol / 4 h / 20 °C View Scheme

potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;

sulfuric acid Reflux;

sulfuric acid in methanol T=20 - 50°C;

thionyl chloride T=0°C; 0.5 h; Heating / reflux;

sulfuric acid; sodium hydrogencarbonate; trimethyl orthoformate in methanol

1.1: H2SO4 / methanol 2.1: K2CO3 / acetone 3.1: N,N-diethylaniline 4.1: aq. NaOH / ethanol 5.1: CDI / tetrahydrofuran 5.2: NH3(gas) / tetrahydrofuran 6.1: 60 percent / potassium nitrite; iodine; 18-crown-6 / pyridine / tetrahydrofuran / 20 °C / sonication 7.1: 97 percent / NaBH4; SiO2 / CHCl3; propan-2-ol / 0.5 h / 20 °C 8.1: 61 percent / hydrazine hydrate / Raney Ni / ethanol; tetrahydrofuran / 1 h / 45 °C View Scheme

4 A molecular sieve; TEA; anhydrous copper acetate in dichloromethane T=20°C; 48 h;