2(1H)-PYRIDINONE,5-CHLORO-3-FLUORO-(9CI)合成路线 （共 8 条）
反应条件
1: With sodium hydroxide; water Heating / reflux; 2: With hydrogenchloride; water pH=1;
参考文献
US2008/242695 A1, ;
Page/Page column 36 ;
反应条件
1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C 2: 92 percent / aq. sodium hydroxide; zinc powder / 6 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=130°C; 1 h;
参考文献
Collibee, Scott; Lu, Pu-Ping; Ashcraft, Luke W.; Browne, William F.; Garard, Marc Andrew; Morgan, Bradley P.; Morgans, David J.; Bergnes, Gustave; Muci, Alex
Patent: US2008/242695 A1, 2008 ;
Location in patent: Page/Page column 36 ;
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=130°C; 2 h;
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
反应条件
1.1: phosphorus oxytribromide / toluene / 4 h / 60 - 110 °C 1.2: 0 °C 2.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C 2.2: -78 - 20 °C 3.1: thionyl chloride / 2 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
反应条件
1.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 71 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: phosphorus oxytribromide / toluene / 4 h / 60 - 110 °C
1.2: 0 °C
2.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C
2.2: -78 - 20 °C
3.1: thionyl chloride / 2 h / Reflux
View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
反应条件
1.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C
2.2: 59 percent / iodine / tetrahydrofuran / 1 h / -75 °C
View Scheme
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
