2-溴-3-氟-5-氯吡啶合成路线 （共 10 条）
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=130°C; 1 h;
参考文献
Collibee, Scott; Lu, Pu-Ping; Ashcraft, Luke W.; Browne, William F.; Garard, Marc Andrew; Morgan, Bradley P.; Morgans, David J.; Bergnes, Gustave; Muci, Alex
Patent: US2008/242695 A1, 2008 ;
Location in patent: Page/Page column 36 ;
反应条件
1: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-75°C; 0.25 h; 2: With methanol
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
反应条件
1: 91 percent / aq. sodium hydroxide / 20 h / 75 °C 2: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
反应条件
sodium hydroxide; zinc T=25°C; 6 h;
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
反应条件
1.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C 1.2: -78 - 20 °C 2.1: thionyl chloride / 2 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
反应条件
in dimethyl sulfoxide T=120°C; 3 h;
参考文献
Collibee, Scott; Lu, Pu-Ping; Ashcraft, Luke W.; Browne, William F.; Garard, Marc Andrew; Morgan, Bradley P.; Morgans, David J.; Bergnes, Gustave; Muci, Alex
Patent: US2008/242695 A1, 2008 ;
Location in patent: Page/Page column 36 ;
反应条件
1: 2-bromo-5-chloro-3-fluoropyridine With n-butyllithium in hexane; toluene T=-75°C; 1 h; 2: carbon dioxide in hexane; toluene
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C 1.2: 59 percent / iodine / tetrahydrofuran / 1 h / -75 °C 2.1: 2 equiv. butyllithium / toluene; hexane / 1 h / -75 °C 2.2: 94 percent / toluene; hexane View Scheme
参考文献
European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
反应条件
1.1: n-butyllithium / toluene; hexane / 0.75 h / -78 °C
1.2: -78 - 20 °C
2.1: thionyl chloride / 2 h / Reflux
View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran
T=0°C; 2 h;
2: With iodine in tetrahydrofuran
T=-75°C; 1 h;
参考文献
Schlosser, Manfred; Bobbio, Carla
European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
