alpha-甲基-3-联苯乙酸合成路线 （共 13 条）
反应条件
1: 1.) aq. NaNO2, concd HCl, 2.) H3PO2 / 1.) DMF, 0 deg C, 2.) DMF, 0-5 deg C, 59 h
2: HCl / 1 h / Heating
3: 66 percent / aq. NaOH, n-Bu4N(HSO4) / CH2Cl2 / 4 h / Ambient temperature
4: 71 percent / aq. NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
反应条件
bis(triphenylphosphine)palladium(O) in tetrahydrofuran
参考文献
Hamon, David P. G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron Letters, 1993 , vol. 34, # 33 p. 5333 - 5336
反应条件
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride; zinc(II) chloride
1.) ether, THF, RT, 10 min, 2.) ether, THF, RT, 1.5 h; Yield given. Multistep reaction;
参考文献
Hamon, David P.G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron, 1995 , vol. 51, # 46 p. 12645 - 12660
