8-苯基-1,4-二oxa-螺[4.5]癸烷-8-羧酸合成路线 （共 8 条）
反应条件
1: 92 percent / acetic acid / 24 h / Heating 2: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
acetic acid
24 h; Heating;
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
potassium hydroxide in water; ethylene glycol
48 h; Heating;
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
potassium hydroxide in 8-Phenyl-1,4-dioxaspirolt;4.5gt;decan-8-carbonitril; ethylene glycol
参考文献
The Upjohn Company
Patent: US4065573 A1, 1977 ;
反应条件
1: 55 percent / p-toluenesulfonic acid / CH2Cl2 / 24 h / Heating
2: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
3: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
The Upjohn Company
Patent: US3979444 A1, 1976 ;
