3-(氨基甲基)-N-甲基苯甲酰胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
72 h;
参考文献
Fitzmaurice, Richard J.; Gaggini, Francesca; Srinivasan, Natarajan; Kilburn, Jeremy D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1706 - 1714
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Baez-Santos, Yahira M.; Barraza, Scott J.; Wilson, Michael W.; Agius, Michael P.; Mielech, Anna M.; Davis, Nicole M.; Baker, Susan C.; Larsen, Scott D.; Mesecar, Andrew D.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2393 - 2412
反应条件
1: SOCl2 / methanol / 18 h / Heating
2: 895 mg / H2O; tetrahydrofuran / 18 h
3: 85 percent / hydrogen / Pd/C / methanol / 72 h
View Scheme
参考文献
Fitzmaurice, Richard J.; Gaggini, Francesca; Srinivasan, Natarajan; Kilburn, Jeremy D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1706 - 1714
反应条件
1: 895 mg / H2O; tetrahydrofuran / 18 h
2: 85 percent / hydrogen / Pd/C / methanol / 72 h
View Scheme
参考文献
Fitzmaurice, Richard J.; Gaggini, Francesca; Srinivasan, Natarajan; Kilburn, Jeremy D.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1706 - 1714
