N-环丙基-3-碘-4-甲基苯甲酰胺合成路线 （共 3 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide)
T=20°C; 4 h;
参考文献
Lang, Hengyuan; Lan, Jiong; Fang, Yunfeng
Patent: US2005/20590 A1, 2005 ;
Location in patent: Page/Page column 16 ;
US 20050020590 A1
反应条件
1: 3-Iodo-4-methyl-benzoic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 1 h;
2: anhydrous cyclopropylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2007/339 A1, 2007 ;
Location in patent: Page/Page column 51 ;
WO 2007/000339 A1
反应条件
sodium carbonate in dichloromethane
T=20°C; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/93248 A1, 2003 ;
Location in patent: Page/Page column 26 ;
WO 03/093248 A1
