(3-硝基苯基)肼氯化物合成路线 （共 13 条）
反应条件
1.1: ethanol / 4 h / 20 °C
2.1: PPA / toluene / Reflux
2.2: Reflux
2.3: pH 1 - 2
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: 3-Nitrophenylhydrazine hydrochloride With N-ethyl-N,N-diisopropylamine in ethanol
T=20°C; 2 h;
2: (ethoxymethylene)malononitrile in ethanol
1 h; Heating / reflux;
参考文献
Nuevolution A/S
Patent: WO2009/152824 A1, 2009 ;
Location in patent: Page/Page column 219-220 ;
反应条件
1: ethanol / 4 h / 20 °C
2: PPA / toluene / Reflux
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
